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Article

A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.

Nature communications - 23 Aug 2021

Guan Yuting, Liang Xiujie, Ma Ziyuan, Hu Hailong, Liu Hongbo, Miao Zhen, Linkermann Andreas, Hellwege Jacklyn N, Voight Benjamin F, Susztak Katalin

Abstract excerpt

Genome-wide association studies (GWAS) have identified loci for kidney disease, but the causal variants, genes, and pathways remain unknown. Here we identify two kidney disease genes Dipeptidase 1 (DPEP1) and Charged Multivesicular Body Protein 1 A (CHMP1A) via the triangulation of kidney function GWAS, human kidney expression, and methylation quantitative trait loci. Using single-cell chromatin accessibility and...

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Identifiers

PMID: 34426578
DOI: 10.1038/s41467-021-25377-x
PMCID: PMC8382756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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