Article
Myeloid FtH Regulates Macrophage Response to Kidney Injury by Modulating Snca and Ferroptosis
2025-03-28
Abstract excerpt
<h4>SUMMARY</h4> This study explored the role of myeloid ferritin heavy chain (FtH) in coordinating kidney iron trafficking in health and disease. Synuclein-α (Snca) was the sole iron-binding protein upregulated in response to myeloid FtH deletion (FtH Δ/Δ ). Following kidney injury, FtH Δ/Δ mice showed worsened kidney function. Transcriptome analysis revealed coupling of FtH deficiency with ferroptosis activat...
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Identifiers and source
- Literature Corpus work
- 2d394b20-2b61-5128-bb40-6ab55f969bc5
- DOI
- 10.1101/2025.03.25.645219