Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation

26 Mar 2025

Abstract excerpt

Pioneer transcription factors (TFs) initiate chromatin remodeling, which is crucial for gene regulation and cell differentiation. In this study, we investigated how the sequential expression of neurogenin 3 (NGN3) and NEUROD1 affects their pioneering functions during pancreatic endocrine differentiation. Using a genetically engineered mouse model, we mapped NGN3-binding sites, confirming the pivotal role of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Genetics and Neurodevelopmental Disorders
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40138419
DOI: 10.1126/sciadv.adt4770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiationPMID 40138419Read ↗

NEUROD1: transcriptional and epigenetic regulator of human and mouse neuronal and endocrine cell lineage programsSemantic proximity Read ↗

NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiationSemantic proximity Read ↗

A combined transcriptional and dynamic roadmap of single human pancreatic endocrine progenitors reveals proliferative capacity and differentiation continuumSemantic proximity Read ↗

Defining Pancreatic Endocrine Precursors and Their DescendantsSemantic proximity Read ↗

Neurogenin3 Cooperates with Foxa2 to Autoactivate Its Own ExpressionSemantic proximity Read ↗

Neurogenin3 Activates the Islet Differentiation Program while Repressing Its Own ExpressionSemantic proximity Read ↗

Transcription factors that shape the mammalian pancreasSemantic proximity Read ↗

Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human PancreasSemantic proximity Read ↗

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory networkSemantic proximity Read ↗

Regulation of the Pancreatic Pro-Endocrine Gene <i>Neurogenin3</i>Semantic proximity Read ↗

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory networkSemantic proximity Read ↗

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.