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PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration

2 Nov 2017

Abstract excerpt

Transcription factors regulate gene expression through binding to specific enhancer sequences. Pancreas/duodenum homeobox protein 1 (PDX1), Neurogenin-3 (NEUROG3), and V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA) are transcription factors critical for beta cell development and maturation. NEUROG3 is expressed in endocrine progenitor cells and controls islet differentiation and regeneration....

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PMID: 29096722
DOI: 10.1186/s13287-017-0694-z

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