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Article

NeuroD: the predicted and the surprising.

Molecules and cells - 31 Dec 2004

Chae Ji Hyung, Stein Gretchen H, Lee Jacqueline E

Abstract excerpt

NeuroD (otherwise known as BETA2) is a basic helix-loop-helix (bHLH) transcription factor that is capable of converting embryonic epidermal cells into fully differentiated neurons in Xenopus embryos. In insulinoma cells, NeuroD can bind and activate the insulin promoter. When NeuroD is deleted in mice, the early differentiating pancreatic endocrine cells and a subset of the neurons in the central and peripheral...

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PMID: 15650322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

NeuroD: the predicted and the surprising.PMID 15650322Read ↗

NEUROD1: transcriptional and epigenetic regulator of human and mouse neuronal and endocrine cell lineage programsSemantic proximity Read ↗

NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the PancreasSemantic proximity Read ↗

Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2.Semantic proximity Read ↗

NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus.Semantic proximity Read ↗

NeuroD1 in the endocrine pancreas: Localization and dual function as an activator and repressorSemantic proximity Read ↗

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus.Semantic proximity Read ↗

Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell–Derived Insulin-Expressing Cells Require NEUROD1Semantic proximity Read ↗

Homozygous mutations in NEUROD1 are responsible for a novel syndrome of permanent neonatal diabetes and neurological abnormalities.Semantic proximity Read ↗

Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion.Semantic proximity Read ↗

Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.Semantic proximity Read ↗

Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.Semantic proximity Read ↗

Neurod1 regulates survival and formation of connections in mouse ear and brain.Semantic proximity Read ↗

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