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Article

Defining Pancreatic Endocrine Precursors and Their Descendants

11 Dec 2007

Abstract excerpt

OBJECTIVE: The global incidence of diabetes continues to increase. Cell replacement therapy and islet transplantation offer hope, especially for severely affected patients. Efforts to differentiate insulin-producing beta-cells from progenitor or stem cells require knowledge of the transcriptional programs that regulate the development of the endocrine pancreas. RESEARCH DESIGN AND METHODS: Differentiation toward...

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Identifiers

PMID: 18071024
DOI: 10.2337/db07-1362

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Related research

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Research trail→

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Defining Pancreatic Endocrine Precursors and Their DescendantsPMID 18071024Read ↗

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The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiationSemantic proximity Read ↗

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A combined transcriptional and dynamic roadmap of single human pancreatic endocrine progenitors reveals proliferative capacity and differentiation continuumSemantic proximity Read ↗

Neurogenin3 Activates the Islet Differentiation Program while Repressing Its Own ExpressionSemantic proximity Read ↗

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas.Semantic proximity Read ↗

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Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitorsSemantic proximity Read ↗

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