Article
Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016
Clark Nathaniel E, Katolik Adam, Roberts Kenneth M, Taylor Alexander B, Holloway Stephen P, Schuermann Jonathan P, Montemayor Eric J, Stevens Scott W, Fitzpatrick Paul F, Damha Masad J, Hart P John
Abstract excerpt
Intron lariats are circular, branched RNAs (bRNAs) produced during pre-mRNA splicing. Their unusual chemical and topological properties arise from branch-point nucleotides harboring vicinal 2',5'- and 3',5'-phosphodiester linkages. The 2',5'-bonds must be hydrolyzed by the RNA debranching enzyme Dbr1 before spliced introns can be degraded or processed into small nucleolar RNA and microRNA derived from intronic...
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