Article

The debranching enzyme Dbr1 regulates lariat turnover and intron splicing

2023-06-13

Abstract excerpt

<title>Abstract</title> <p>The majority of genic transcription is intronic. Introns are removed by splicing as branched lariat RNAs which require rapid recycling. The branch site is recognized during splicing catalysis and later debranched by Dbr1 in the rate-limiting step of lariat turnover. Through generation of the first viable DBR1 knockout cell line, we find the predominantly nuclear Dbr1 enzyme to encode th...

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Literature Corpus work: 0a12003e-8573-5452-9602-8668ebe4a0c3
DOI: 10.21203/rs.3.rs-2931976/v1

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