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Article

Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.

Nucleic acids research - 27 Jul 2015

Wang Vivien Ya-Fan, Jiao Xinfu, Kiledjian Megerditch, Tong Liang

Abstract excerpt

Recent studies showed that Rai1 and its homologs are a crucial component of the mRNA 5'-end capping quality control mechanism. They can possess RNA 5'-end pyrophosphohydrolase (PPH), decapping, and 5'-3' exonuclease (toward 5' monophosphate RNA) activities, which help to degrade mRNAs with incomplete 5'-end capping. A single active site in the enzyme supports these apparently distinct activities. However, each...

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PMID: 26101253
DOI: 10.1093/nar/gkv620
PMCID: PMC4513879

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