Article
Probing the catalytic triad of an archaeal RNA splicing endonuclease.
Biochemistry - 23 Dec 2008
Calvin Kate, Xue Song, Ellis Charles, Mitchell Michelle H, Li Hong
Abstract excerpt
Among the four known mechanisms of intron removal, three are reputedly catalyzed by RNA molecules. In the fourth mechanism, a protein endonuclease removes introns from nuclear tRNA and all archaeal RNAs. Three strictly conserved residues of the splicing endonuclease, a histidine, a lysine, and a tyrosine, were predicted to catalyze the intron cleavage reaction in a manner similar to that of the catalytic triad of...
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