Structure and mechanism of a metal-sensing regulatory RNA.

doi:10.1016/j.cell.2007.06.051

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Article

Structure and mechanism of a metal-sensing regulatory RNA.

Cell - 7 Sept 2007

Dann Charles E, Wakeman Catherine A, Sieling Cecelia L, Baker Stephanie C, Irnov Irnov, Winkler Wade C

Abstract excerpt

Organisms maintain the correct balance of intracellular metals primarily through metal-sensing proteins that control transport and storage of the target ion(s). Here, we reveal the basis of metal sensing and genetic control by a metalloregulatory RNA. Our data demonstrate that a previously uncharacterized orphan riboswitch, renamed the "M-box," is a divalent metal-sensing RNA involved in Mg(2+) homeostasis. A...

Topics

5' Untranslated Regions
Antiporters
Bacillus subtilis
Bacterial Proteins
Base Sequence
Crystallography
Gene Expression Regulation, Bacterial
Genes, Reporter
Homeostasis
Lac Operon
Magnesium Chloride
Models, Molecular
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 17803910
DOI: 10.1016/j.cell.2007.06.051

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

RNA, Bacterial

RNA, Messenger

Recombinant Fusion Proteins