Article
Structure and mechanism of a metal-sensing regulatory RNA.
Cell - 7 Sept 2007
Dann Charles E, Wakeman Catherine A, Sieling Cecelia L, Baker Stephanie C, Irnov Irnov, Winkler Wade C
Abstract excerpt
Organisms maintain the correct balance of intracellular metals primarily through metal-sensing proteins that control transport and storage of the target ion(s). Here, we reveal the basis of metal sensing and genetic control by a metalloregulatory RNA. Our data demonstrate that a previously uncharacterized orphan riboswitch, renamed the "M-box," is a divalent metal-sensing RNA involved in Mg(2+) homeostasis. A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.