Article
Mitochondrial Aging: Is There a Mitochondrial Clock?
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2017
Zorov Dmitry B, Popkov Vasily A, Zorova Ljubava D, Vorobjev Ivan A, Pevzner Irina B, Silachev Denis N, Zorov Savva D, Jankauskas Stanislovas S, Babenko Valentina A, Plotnikov Egor Y
Abstract excerpt
Fragmentation (fission) of mitochondria, occurring in response to oxidative challenge, leads to heterogeneity in the mitochondrial population. It is assumed that fission provides a way to segregate mitochondrial content between the "young" and "old" phenotype, with the formation of mitochondrial "garbage," which later will be disposed. Fidelity of this process is the basis of mitochondrial homeostasis, which is...
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