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Article

Unopposed mitochondrial fission leads to severe lifespan shortening.

Cell cycle (Georgetown, Tex.) - 15 Sept 2011

Scheckhuber Christian Q, Wanger Ruth A, Mignat Cora A, Osiewacz Heinz D

Abstract excerpt

Mitochondrial morphology is controlled by the opposing processes of fusion and fission. Previously, in baker's yeast it was shown that reduced mitochondrial fission leads to a network-like morphology, decreased sensitivity for the induction of apoptosis and a remarkable extension of both replicative and chronological lifespan. However, the effects of reduced mitochondrial fusion on aging are so far unknown and...

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Source

Identifiers

PMID: 21912203
DOI: 10.4161/cc.10.18.17196

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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