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Article

A proposed refinement of the mitochondrial free radical theory of aging.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Feb 1997

de Grey A D

Abstract excerpt

Over recent years, evidence has been accumulating in favour of the free radical theory of aging, first proposed by Harman. Despite this, an understanding of the mechanism by which cells might succumb to the effects of free radicals has proved elusive. This paper proposes such a mechanism, based on a previously unexplored hypothesis for the proliferation of mutant mitochondrial DNA: that mitochondria with reduced...

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PMID: 9046246
DOI: 10.1002/bies.950190211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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