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Article

A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.

PLoS genetics - 1 Dec 2016

Klabonski Lauren, Zha Ji, Senthilkumar Lakshana, Gidalevitz Tali

Abstract excerpt

Misfolded proteins in transgenic models of conformational diseases interfere with proteostasis machinery and compromise the function of many structurally and functionally unrelated metastable proteins. This collateral damage to cellular proteins has been termed 'bystander' mechanism. How a single misfolded protein overwhelms the proteostasis, and how broadly-expressed mutant proteins cause cell type-selective...

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PMID: 27926939
DOI: 10.1371/journal.pgen.1006450
PMCID: PMC5142776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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