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Article

The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo

29 Sept 2010

Abstract excerpt

The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. We use genetic reporters to demonstrate activation of the unfolded protein response in a transgenic Drosophila model of Alzheimer's disease and related tauopathies. We...

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PMID: 20927324
DOI: 10.1371/journal.pone.0013084

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