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Article

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.

Genes & development - 15 Nov 2007

Garcia Susana M, Casanueva M Olivia, Silva M Catarina, Amaral Margarida D, Morimoto Richard I

Abstract excerpt

Protein homeostasis maintains proper intracellular balance by promoting protein folding and clearance mechanisms while minimizing the stress caused by the accumulation of misfolded and damaged proteins. Chronic expression of aggregation-prone proteins is deleterious to the cell and has been linked to a wide range of conformational disorders. The molecular response to misfolded proteins is highly conserved and...

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Identifiers

PMID: 18006691
DOI: 10.1101/gad.1575307
PMCID: PMC2049200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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