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Article

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.

Nature communications - 30 Sept 2019

Waldherr Sarah M, Strovas Timothy J, Vadset Taylor A, Liachko Nicole F, Kraemer Brian C

Abstract excerpt

To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular compartment-specific manner, but others exhibit trans-compartmental mechanisms of proteostasis. To identify pathways protecting neurons from pathological tau protein, we employed a transgenic Caenorhabditis elegans model of human tauopathy...

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Identifiers

PMID: 31570707
DOI: 10.1038/s41467-019-12070-3
PMCID: PMC6768869

Genes

ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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