Article
Donor Genotype and Intragraft Expression of CYP3A5 Reflect the Response to Steroid Treatment During Acute Renal Allograft Rejection.
Transplantation - 1 Sept 2017
Rekers Niels Vincent, Flaig Tanja M, Mallat Marko J K, Spruyt-Gerritse Marijke J, Zandbergen Malu, Anholts Jacqueline D H, Bajema Ingeborg M, Clahsen-van Groningen Marian C, Yang Jianxin, de Fijter Johan W, Claas Frans H J, Brakemeier Susanne, Lachmann Nils, Kreutz Reinhold, de Heer Emile, Budde Klemens, Bolbrinker Juliane, Eikmans Michael
Abstract excerpt
BACKGROUND: Glucocorticoid (GC)-refractory acute rejection (AR) is a risk factor for inferior renal allograft outcome. We investigated genetic predisposition to the response to steroid treatment of acute allograft rejection. METHODS: Single nucleotide polymorphisms of genes involved in GC signaling (GR, GLCCI1) and drug metabolism and transport (CYP3A5, ABCB1, and PXR) were analyzed in kidney transplant...
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