Article
Association of plasminogen activator inhibitor-1 genotype with avascular osteonecrosis in steroid-treated renal allograft recipients.
Transplantation - 27 Oct 2002
Ferrari Paolo, Schroeder Verena, Anderson Suzanne, Kocovic Leonardo, Vogt Bruno, Schiesser Daniela, Marti Hans-Peter, Ganz Reinhold, Frey Felix J, Kohler Hans P
Abstract excerpt
BACKGROUND: The mechanism of avascular osteonecrosis (AVN) is controversial. Besides an increased bone marrow pressure with reduced blood supply, an enhanced coagulation has been considered. We hypothesize that a genetic variant of the plasminogen activator inhibitor-1 (PAI-1) determines the risk...
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