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Article

Expression of CYP3A5 and P-glycoprotein in renal allografts with histological signs of calcineurin inhibitor nephrotoxicity.

Transplantation - 27 May 2011

Metalidis Christoph, Lerut Evelyne, Naesens Maarten, Kuypers Dirk R J

Abstract excerpt

BACKGROUND: Susceptibility to calcineurin inhibitor nephrotoxicity (CNIT) after solid organ transplantation could be related to an interindividual variability in renal expression and function of the metabolizing cytochrome P450 3A5 (CYP3A5) isoenzyme and of the multidrug efflux transporter P-glycoprotein (P-gp, ABCB1). METHODS: We compared renal expression of CYP3A5 and P-gp, measured by immunohistochemistry, in...

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Source

Identifiers

PMID: 21544031
DOI: 10.1097/TP.0b013e3182177502

Genes

ABCB1

Variants

rs776746
rs776746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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