Article
Plasminogen activator inhibitor-1 polymorphism is associated with progressive renal dysfunction after acute rejection in renal transplant recipients.
Transplantation - 27 Dec 2002
Chow Kai Ming, Szeto Cheuk Chun, Szeto Carol Yi-Ki, Poon Peter, Lai Fernand Mac-Moune, Li Philip Kam-Tao
Abstract excerpt
BACKGROUND: Plasma level of plasminogen activator inhibitor (PAI)-1 is genetically determined by a polymorphism in the promoter region, involving two alleles, 4G and 5G. Plasma PAI-1 concentrations are higher in subjects homozygous for the 4G allele than other genotypes (5G/5G and 4G/5G). Such ge...
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