Article
GLCCI1 and Glucocorticoid Receptor Genetic Diversity and Response to Glucocorticoid-Based Treatment of Graft-versus-Host Disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jul 2015
O'Meara Alix, Boukouaci Wahid, Robin Marie, Xhaard Aliénor, Fortier Catherine, Marzais François, Sicre de Fontbrune Flore, Peffault de Latour Régis, Charron Dominique, Socié Gerard, Tamouza Ryad
Abstract excerpt
The genetic diversity of loci implicated in glucocorticoid (GC) response has been associated with interindividual variations in responsiveness to GC in various diseases, such as asthma and inflammatory bowel disorders. In acute graft-versus-host disease (aGVHD), similar differences of first-line therapy responsiveness are also observed, with approximately 40% of patients failing to respond to GC. Here, the...
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