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Article

Clinical impact of glucocorticoid responsiveness-related gene polymorphism on graft-versus-host disease and survival after single-unit cord blood transplantation.

International journal of hematology - 1 Mar 2026

Konuma Takaaki, Hamatani-Asakura Megumi, Monna-Oiwa Maki, Kato Seiko, Andoh Shohei, Ichimura Hirona, Yokoyama Kazuaki, Nannya Yasuhito, Takahashi Satoshi

Abstract excerpt

Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic cell transplantation (HCT), and glucocorticoids remain the standard first-line treatment. However, glucocorticoid responses vary widely and are influenced by genetic polymorphisms in glucocorticoid signaling pathways. Their impact after cord blood transplantation (CBT) is unclear. We retrospectively analyzed adult patients who...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41264074
DOI: 10.1007/s12185-025-04112-y
PMCID: PMC12967668

Genes

GLCCI1
NR3C1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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