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Article

The Genetic Evolution of Metastasis.

Cancer research - 16 May 2022

Rogiers Aljosja, Lobon Irene, Spain Lavinia, Turajlic Samra

Abstract excerpt

Cancer is an evolutionary process that is characterized by the emergence of multiple genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity provides a substrate for the selection of adaptive clones, such as those that lead to metastasis. Comparative molecular studies of primary tumors and metastases have identified distinct genomic features associated with the development of...

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PMID: 35476646
DOI: 10.1158/0008-5472.CAN-21-3863

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