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Article

Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos.

Journal of assisted reproduction and genetics - 1 Jun 2024

Bekaert B, Boel A, Rybouchkin A, Cosemans G, Declercq S, Chuva de Sousa Lopes S M, Parrington J, Stoop D, Coucke P, Menten B, Heindryckx B

Abstract excerpt

PURPOSE: Unpredictable genetic modifications and chromosomal aberrations following CRISPR/Cas9 administration hamper the efficacy of germline editing. Repair events triggered by double-strand DNA breaks (DSBs) besides non-homologous end joining and repair template-driven homology-directed repair have been insufficiently investigated in mouse. In this work, we are the first to investigate the precise repair...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38557805
DOI: 10.1007/s10815-024-03095-9
PMCID: PMC11224219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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