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OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Ojewole Adegoke, Lowegard Anna, Gainza Pablo, Reeve Stephanie M, Georgiev Ivelin, Anderson Amy C, Donald Bruce R

Abstract excerpt

Drug resistance in protein targets is an increasingly common phenomenon that reduces the efficacy of both existing and new antibiotics. However, knowledge of future resistance mutations during pre-clinical phases of drug development would enable the design of novel antibiotics that are robust against not only known resistant mutants, but also against those that have not yet been clinically observed. Computational...

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Identifiers

PMID: 27914058
DOI: 10.1007/978-1-4939-6637-0_15
PMCID: PMC5192561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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