Article

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase

2018-07-17

Abstract excerpt

Staphylococcal species are a leading cause of bacterial drug-resistant infections and associated mortality. One strategy to combat bacterial drug resistance is to revisit compromised targets, and to circumvent resistance mechanisms using structure-assisted drug discovery. The folate pathway is an ideal candidate for this approach. Antifolates target an essential metabolic pathway, and the necessary detailed struct...

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Literature Corpus work: 9d4394db-1467-5fdd-b3cc-67f45c2f6e3e
DOI: 10.3389/fmicb.2018.01369

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