Characterization and targeting of deleterious mutations in Carbapenemase-producing Klebsiella pneumoniae: insights from variant calling, Computer-aided drug design, and DFT analysis.

Abstract excerpt

The emergence of Carbapenemase-producing Klebsiella pneumoniae (CP-KP) strains is becoming a significant global concern. Rising resistance rates in these strains significantly impact available treatment options. Therefore, this present research aims to identify the existence of antibiotic-resistance genes in clinical isolates of CP-KP strains. Whole-genome sequencing data from 17 CP-KP isolates were analyzed to...

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