Article
Predicting resistance mutations using protein design algorithms.
Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010
Frey Kathleen M, Georgiev Ivelin, Donald Bruce R, Anderson Amy C
Abstract excerpt
Drug resistance resulting from mutations to the target is an unfortunate common phenomenon that limits the lifetime of many of the most successful drugs. In contrast to the investigation of mutations after clinical exposure, it would be powerful to be able to incorporate strategies early in the development process to predict and overcome the effects of possible resistance mutations. Here we present a unique...
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