Article
Global analysis of protein folding using massively parallel design, synthesis, and testing.
Science (New York, N.Y.) - 14 Jul 2017
Rocklin Gabriel J, Chidyausiku Tamuka M, Goreshnik Inna, Ford Alex, Houliston Scott, Lemak Alexander, Carter Lauren, Ravichandran Rashmi, Mulligan Vikram K, Chevalier Aaron, Arrowsmith Cheryl H, Baker David
Abstract excerpt
Proteins fold into unique native structures stabilized by thousands of weak interactions that collectively overcome the entropic cost of folding. Although these forces are "encoded" in the thousands of known protein structures, "decoding" them is challenging because of the complexity of natural proteins that have evolved for function, not stability. We combined computational protein design, next-generation gene...
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