Article
Protein design algorithms predict viable resistance to an experimental antifolate.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 2015
Reeve Stephanie M, Gainza Pablo, Frey Kathleen M, Georgiev Ivelin, Donald Bruce R, Anderson Amy C
Abstract excerpt
Methods to accurately predict potential drug target mutations in response to early-stage leads could drive the design of more resilient first generation drug candidates. In this study, a structure-based protein design algorithm (K* in the OSPREY suite) was used to prospectively identify single-nucleotide polymorphisms that confer resistance to an experimental inhibitor effective against dihydrofolate reductase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.