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Article

Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.

Antimicrobial agents and chemotherapy - 1 Jul 2012

Frey Kathleen M, Viswanathan Kishore, Wright Dennis L, Anderson Amy C

Abstract excerpt

Resistance to trimethoprim (TMP) resulting from point mutations in the enzyme drug target dihydrofolate reductase (DHFR) drives the development of new antifolate inhibitors effective against methicillin-resistant Staphylococcus aureus (MRSA). For the past several years we have used structure-base...

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Source

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Identifiers

PMID: 22491688
DOI: 10.1128/AAC.06263-11
PMCID: PMC3393473

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22491688-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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