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Article

Predicting antifolate resistance in the unculturable fungal pathogen Pneumocystis jirovecii.

PLoS genetics - 1 May 2026

Rouleau Francois D, Dubé Alexandre K, Pageau Alicia, Désautels Lyne, Dufresne Philippe J, Landry Christian R

Abstract excerpt

Pneumocystis jirovecii is an opportunistic fungal pathogen responsible for Pneumocystis pneumonia (PCP) in immunocompromised patients. Antifolate drugs targeting the dihydrofolate reductase (DHFR), including trimethoprim (TMP), remain central to treatment, but studying the effects of mutations in DHFR on resistance to treatment is limited by our inability to culture this organism in vitro or in animal models. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42201980
DOI: 10.1371/journal.pgen.1012163
PMCID: PMC13241008

Genes

DHFR

Provenance

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Predicting antifolate resistance in the unculturable fungal pathogen Pneumocystis jirovecii.PMID 42201980Read ↗

Predicting antifolate resistance in the unculturable fungal pathogen <i>Pneumocystis jirovecii</i>Semantic proximity Read ↗

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