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Article

RESISTOR: A New OSPREY Module to Predict Resistance Mutations.

Journal of computational biology : a journal of computational molecular cell biology - 1 Dec 2022

Guerin Nathan, Kaserer Teresa, Donald Bruce R

Abstract excerpt

Computational, in silico prediction of resistance-conferring escape mutations could accelerate the design of therapeutics less prone to resistance. This article describes how to use the Resistor algorithm to predict escape mutations. Resistor employs Pareto optimization on four resistance-conferring criteria-positive and negative design, mutational probability, and hotspot cardinality-to assign a Pareto rank to...

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Identifiers

PMID: 36099194
DOI: 10.1089/cmb.2022.0254
PMCID: PMC9807075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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