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Article

Resistor: An algorithm for predicting resistance mutations via Pareto optimization over multistate protein design and mutational signatures.

Cell systems - 19 Oct 2022

Guerin Nathan, Feichtner Andreas, Stefan Eduard, Kaserer Teresa, Donald Bruce R

Abstract excerpt

Resistance to pharmacological treatments is a major public health challenge. Here, we introduce Resistor-a structure- and sequence-based algorithm that prospectively predicts resistance mutations for drug design. Resistor computes the Pareto frontier of four resistance-causing criteria: the change in binding affinity (ΔKa) of the (1) drug and (2) endogenous ligand upon a protein's mutation; (3) the probability a...

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Identifiers

PMID: 36265469
DOI: 10.1016/j.cels.2022.09.003
PMCID: PMC9589925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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