Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles

2 Dec 2016

Abstract excerpt

The dendritic cell signals required for the in vivo priming of IL-4-producing T cells are unknown. We used RNA sequencing to characterize DCs from skin LN of mice exposed to two different Th2 stimuli: the helminth parasite Nippostrongylus brasiliensis (Nb) and the contact sensitizer dibutyl phthalate (DBP)-FITC. Both Nb and DBP-FITC induced extensive transcriptional changes that involved multiple DC subsets....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to IL-33, ST2, and ILC Pathways
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27913566
DOI: 10.1084/jem.20160470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Th2 responses are primed by skin dendritic cells with distinct transcriptional profilesPMID 27913566Read ↗

Interferon response factor-3 promotes the pro-Th2 activity of mouse lung CD11b+ conventional dendritic cells in response to house dust mite allergens.Semantic proximity Read ↗

Differential activation profiles of multiple transcription factors during dendritic cell maturation.Semantic proximity Read ↗

Transcriptome profiling of pathogen-specific CD4 T cells identifies T-cell-intrinsic caspase-1 as an important regulator of Th17 differentiationSemantic proximity Read ↗

Dendritic Cell-Mediated Th2 Immunity and Immune DisordersSemantic proximity Read ↗

Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells.Semantic proximity Read ↗

Th2 single-cell heterogeneity and clonal interorgan distribution in helminth-infected miceSemantic proximity Read ↗

Regulation of Th2 Cell Immunity by Dendritic CellsSemantic proximity Read ↗

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cellsSemantic proximity Read ↗

Infective Larvae of Brugia malayi Induce Polarization of Host Macrophages that Helps in Immune Evasion.Semantic proximity Read ↗

<i>Trichinella spiralis</i> antigens prime mixed Th1/Th2 response but do not induce <i>de novo</i> generation of Foxp3<sup>+</sup> T cells <i>in vitro</i>Semantic proximity Read ↗

Reduced pro-inflammatory dendritic cell phenotypes are a potential indicator of successful peanut oral immunotherapy.Semantic proximity Read ↗

CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.