Article
CCL17 production by dendritic cells is required for NOD1-mediated exacerbation of allergic asthma.
American journal of respiratory and critical care medicine - 15 Apr 2014
Ait Yahia Saliha, Azzaoui Imane, Everaere Laetitia, Vorng Han, Chenivesse Cécile, Marquillies Philippe, Duez Catherine, Delacre Myriam, Grandjean Teddy, Balsamelli Joanne, Fanton d'Andon Martine, Fan Ying, Ple Coline, Werts Catherine, Boneca Ivo Gomperts, Wallaert Benoit, Chamaillard Mathias, Tsicopoulos Anne
Abstract excerpt
RATIONALE: Pattern recognition receptors are attractive targets for vaccine adjuvants, and polymorphisms of the innate receptor NOD1 have been associated with allergic asthma. OBJECTIVES: To elucidate whether NOD1 agonist may favor allergic asthma in humans through activation of dendritic cells, and to evaluate the mechanisms involved using an in vivo model. METHODS: NOD1-primed dendritic cells from allergic and...
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