Article
Reduced pro-inflammatory dendritic cell phenotypes are a potential indicator of successful peanut oral immunotherapy.
PloS one - 1 Jan 2022
Anvari Sara, Watkin Levi B, Minard Charles G, Schuster Kimberly, Hassan Oluwatomi, Anagnostou Aikaterini, Orange Jordan S, Corry David B, Davis Carla M
Abstract excerpt
Dendritic cells are important mediators in the early presentation of antigen and regulation of the differentiation of T cells. Peanut oral immunotherapy (POIT) results in desensitization in most peanut allergic individuals (responders), but not in others due to allergic reactions (non-responders). Delineation of early immunologic changes contributing to desensitization would help clarify the POIT mechanism of...
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