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Article

Compensatory evolution to DNA replication stress is robust to nutrient availability.

Molecular systems biology - 1 Oct 2025

Natalino Mariana, Fumasoni Marco

Abstract excerpt

Evolutionary repair refers to the compensatory evolution that follows perturbations in cellular processes. While evolutionary trajectories are often reproducible, other studies suggest they are shaped by genotype-by-environment (GxE) interactions. Here, we test the predictability of evolutionary repair in response to DNA replication stress-a severe perturbation impairing the conserved mechanisms of DNA synthesis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40571846
DOI: 10.1038/s44320-025-00127-z
PMCID: PMC12494895

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