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Article

The ORC1 Cycle in Human Cells

1 Oct 2003

Abstract excerpt

Components of ORC (the origin recognition complex) are highly conserved among eukaryotes and are thought to play an essential role in the initiation of DNA replication. The level of the largest subunit of human ORC (ORC1) during the cell cycle was studied in several human cell lines with a specific antibody. In all cell lines, ORC1 levels oscillate: ORC1 starts to accumulate in mid-G1 phase, reaches a peak at the...

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Identifiers

PMID: 12909627
DOI: 10.1074/jbc.m307534200

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The ORC1 Cycle in Human CellsPMID 12909627Read ↗

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