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Article

Methylation of Breast Cancer Predisposition Genes in Early-Onset Breast Cancer: Australian Breast Cancer Family Registry.

PloS one - 1 Jan 2016

Scott Cameron M, Joo JiHoon Eric, O'Callaghan Neil, Buchanan Daniel D, Clendenning Mark, Giles Graham G, Hopper John L, Wong Ee Ming, Southey Melissa C

Abstract excerpt

DNA methylation can mimic the effects of both germline and somatic mutations for cancer predisposition genes such as BRCA1 and p16INK4a. Constitutional DNA methylation of the BRCA1 promoter has been well described and is associated with an increased risk of early-onset breast cancers that have BRCA1-mutation associated histological features. The role of methylation in the context of other breast cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27902704
DOI: 10.1371/journal.pone.0165436
PMCID: PMC5130174

Genes

BRCA1
MLH1
PALB2
ATM
BRCA2
CDH1
CHEK2
FANCM
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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