Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients.

Human molecular genetics - 1 Apr 2009

Flanagan James M, Munoz-Alegre Marta, Henderson Stephen, Tang Thomas, Sun Ping, Johnson Nichola, Fletcher Olivia, Dos Santos Silva Isabel, Peto Julian, Boshoff Chris, Narod Steven, Petronis Arturas

Abstract excerpt

Bilaterality of breast cancer is an indicator of constitutional cancer susceptibility; however, the molecular causes underlying this predisposition in the majority of cases is not known. We hypothesize that epigenetic misregulation of cancer-related genes could partially account for this predisposition. We have performed methylation microarray analysis of peripheral blood DNA from 14 women with bilateral breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Gene Expression Regulation, Enzymologic

Share to Genes, Neoplasm

Share to Protein Serine-Threonine Kinases

Share to Repetitive Sequences, Nucleic Acid

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19153073
DOI: 10.1093/hmg/ddp033
PMCID: PMC2655767

Genes

ATM
BRCA1
BRCA2
CDH1
CDH13
CHEK2
ESR1
GSTP1
HIC1
MLH1
PGR
RARB
SFN
SFRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients.PMID 19153073Read ↗

Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation-negative early-onset and high-risk breast cancer patients.Semantic proximity Read ↗

Blood DNA methylation biomarkers for breast cancer riskSemantic proximity Read ↗

Peripheral blood DNA methylation analysis reveals epigenetic marks associated with hereditary breast and ovarian cancer riskSemantic proximity Read ↗

Association of common ATM polymorphism with bilateral breast cancer.Semantic proximity Read ↗

DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controlsSemantic proximity Read ↗

Methylation of Breast Cancer Predisposition Genes in Early-Onset Breast Cancer: Australian Breast Cancer Family Registry.Semantic proximity Read ↗

Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer.Semantic proximity Read ↗

Breast cancer family history and allele-specific DNA methylation in the legacy girls study.Semantic proximity Read ↗

Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.Semantic proximity Read ↗

Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.Semantic proximity Read ↗

Promoter Hypermethylation of the ATM Gene as a Novel Biomarker for Breast CancerSemantic proximity Read ↗

ATM, radiation, and the risk of second primary breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.