Article
Genetic variants in epigenetic genes and breast cancer risk.
Carcinogenesis - 1 Aug 2006
Cebrian Arancha, Pharoah Paul D, Ahmed Shahana, Ropero Santiago, Fraga Mario F, Smith Paula L, Conroy Don, Luben Robert, Perkins Barbara, Easton Douglas F, Dunning Alison M, Esteller Manel, Ponder Bruce A J
Abstract excerpt
Epigenetic events, resulting changes in gene expression capacity, are important in tumour progression, and variation in genes involved in epigenetic mechanisms might therefore be important in cancer susceptibility. To evaluate this hypothesis, we examined common variants in 12 genes coding for DNA methyltransferases (DNMT), histone acetyltransferases, histone deacetyltransferases, histone methyltrasferases and...
Topics
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
- Case-Control Studies
- Epigenesis, Genetic
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Homozygote
- Humans
- Middle Aged