Article

Peripheral blood DNA methylation analysis reveals epigenetic marks associated with hereditary breast and ovarian cancer risk

2023-09-22

Abstract excerpt

<title>Abstract</title> Background. Only a fraction of 15-20% of hereditary breast and ovarian cancer (HBOC) patients carry pathogenic coding genetic variants. Therefore, other pathogenic molecular mechanisms could explain the etiopathology of the syndrome. Aberrant germline DNA methylation in tumor suppressors has been reported in HBOC. Methods. We aimed to discover novel methylation marks associated with HBO...

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Literature Corpus work: 5c22ee78-ee2c-5f2f-a3dd-b722d2f8c55e
DOI: 10.21203/rs.3.rs-3297213/v1

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