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Article

Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.

Genome biology - 29 Nov 2016

Sams Aaron J, Dumaine Anne, Nédélec Yohann, Yotova Vania, Alfieri Carolina, Tanner Jerome E, Messer Philipp W, Barreiro Luis B

Abstract excerpt

BACKGROUND: The 2'-5' oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry in non-African populations; yet, strong evidence of positive selection in the OAS region is still lacking. RESULTS: Here we used a broad array of selection tests in concert with neutral coalescent simulations to demonstrate a...

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Share to 2',5'-Oligoadenylate Synthetase
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Immunity, Innate

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Source

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Identifiers

PMID: 27899133
DOI: 10.1186/s13059-016-1098-6
PMCID: PMC5129249

Genes

OAS1
OAS2
OAS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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