Article

Genetic regulation of<i>OAS1</i>nonsense-mediated decay underlies association with risk of severe COVID-19

2021-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Genomic regions have been associated with COVID-19 susceptibility and outcomes, including the chr12q24.13 locus encoding antiviral proteins OAS1-3. Here, we report genetic, functional, and clinical insights into genetic associations within this locus. In Europeans, the risk of hospitalized vs. non-hospitalized COVID-19 was associated with a single 19Kb-haplotype comprised of 76 OAS1 variants incl...

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Literature Corpus work: 3f8e7911-737f-5113-8e62-c817f5c0e7a6
DOI: 10.1101/2021.07.09.21260221

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