Article
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries.
Nature genetics - 1 Aug 2022
Banday A Rouf, Stanifer Megan L, Florez-Vargas Oscar, Onabajo Olusegun O, Papenberg Brenen W, Zahoor Muhammad A, Mirabello Lisa, Ring Timothy J, Lee Chia-Han, Albert Paul S, Andreakos Evangelos, Arons Evgeny, Barsh Greg, Biesecker Leslie G, Boyle David L, Brahier Mark S, Burnett-Hartman Andrea, Carrington Mary, Chang Euijin, Choe Pyoeng Gyun, Chisholm Rex L, Colli Leandro M, Dalgard Clifton L, Dude Carolynn M, Edberg Jeff, Erdmann Nathan, Feigelson Heather S, Fonseca Benedito A, Firestein Gary S, Gehring Adam J, Guo Cuncai, Ho Michelle, Holland Steven, Hutchinson Amy A, Im Hogune, Irby Les'Shon, Ison Michael G, Joseph Naima T, Kim Hong Bin, Kreitman Robert J, Korf Bruce R, Lipkin Steven M, Mahgoub Siham M, Mohammed Iman, Paschoalini Guilherme L, Pacheco Jennifer A, Peluso Michael J, Rader Daniel J, Redden David T, Ritchie Marylyn D, Rosenblum Brooke, Ross M Elizabeth, Anna Hanaisa P Sant, Savage Sharon A, Sharma Sudha, Siouti Eleni, Smith Alicia K, Triantafyllia Vasiliki, Vargas Joselin M, Vargas Jose D, Verma Anurag, Vij Vibha, Wesemann Duane R, Yeager Meredith, Yu Xu, Zhang Yu, Boulant Steeve, Chanock Stephen J, Feld Jordan J, Prokunina-Olsson Ludmila
Abstract excerpt
The chr12q24.13 locus encoding OAS1-OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this locus in relation to COVID-19 severity. In our analysis of patients of European (n = 2,249) and African (n = 835) ancestries with hospitalized versus nonhospitalized COVID-19, the risk of hospitalized disease...
Read the complete abstract on PubMed