Article

Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans

2016-05-03

Abstract excerpt

The 2’-5’ oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry in non-African populations; yet, strong evidence of positive selection in the OAS region is still lacking. Here we used a broad array of selection tests in concert with neutral coalescent simulations to firmly demonstrate a signal of adap...

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Literature Corpus work: 935d904c-0828-5780-ace0-715af1c7c93a
DOI: 10.1101/051466

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