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Article

Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.

Clinical epigenetics - 1 Jan 2016

Zaghlool Shaza B, Al-Shafai Mashael, Al Muftah Wadha A, Kumar Pankaj, Gieger Christian, Waldenberger Melanie, Falchi Mario, Suhre Karsten

Abstract excerpt

BACKGROUND: Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers of inherited information. At the population level, the methylation state of such "heritable" CpG sites is expected to follow a trimodal distribution, and their mode of inheritance...

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Identifiers

PMID: 27895808
DOI: 10.1186/s13148-016-0295-1
PMCID: PMC5120560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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